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Updated: Feb 16, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Gastro-Esophageal Reflux Disease and Malignant Progression - Equal Risk for Men and Women?]
1Department for Gastroenterology and Interventional Endoscopy, Krankenhaus Barmherzige Brüder, Regensburg.
Abstract:
Gastroesophageal reflux disease (GERD) is highly prevalent in the Western world. Patients with GERD have a 10-fold increased risk to develop a Barrett's esophagus. Patients with Barrett's esophagus have a higher risk for an esophageal adenocarcinoma. Men have more severe reflux with a higher grade of inflammation and acid reflux. This seems to be the reason why men develop a Barrett's esophagus more frequently - the risk is approximately 2-3-fold and the risk for an esophageal adenocarcinoma is even 3-6 times higher.
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