Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Retinal cotton-wool-like spots: a marker for AIDS?

P P Pezzi1, S Tamburi, G P D'offizi

  • 1Institute of Ophthalmology, University of Rome, La Sapienza, Italy.

Annals of Ophthalmology
|January 1, 1989
PubMed
Summary

Ocular manifestations like cotton-wool spots in HIV patients correlate with immune decline. These eye changes can predict disease progression, similar to opportunistic infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HCV and diabetes: towards a 'Sustained' glycaemic improvement after treatment with DAAs? - Authors' reply.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

Short-term in vivo modifications of platelet NADPH oxidase 2 (NOX2) and prostaglandin F<sub>2α</sub> in HIV-1 patients on abacavir-based therapies.

HIV medicine·2016
Same author

Rapid decline of fasting glucose in HCV diabetic patients treated with direct-acting antiviral agents.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2016
Same author

Biliodigestive fistulae and gallstone ileus: diagnostic and therapeutic considerations. Our experience.

Il Giornale di chirurgia·2014
Same author

Small bowel intussussception due to metastatic melanoma of unknown primary site. Case report.

Il Giornale di chirurgia·2014
Same author

Detection and quantification of EBV, HHV-6 and CMV DNA in the gastrointestinal tract of HIV-positive patients.

Infection·2014

Area of Science:

  • Ophthalmology
  • Immunology
  • Infectious Diseases

Background:

  • Ocular manifestations are common in Human Immunodeficiency Virus (HIV) infection.
  • Understanding their prognostic value is crucial for managing HIV/AIDS patients.

Purpose of the Study:

  • To investigate the prognostic significance of ocular findings in HIV-infected individuals.
  • To correlate these ocular changes with immune status, specifically CD4+ lymphocyte counts.

Main Methods:

  • Longitudinal study with an average follow-up of one year (3-22 months).
  • Ophthalmoscopic examinations to identify and document ocular manifestations.
  • Monitoring of CD4+ lymphocyte counts to assess immune status.

Main Results:

  • Retinal cotton-wool-like spots were the most frequent ocular finding (58.8% in AIDS, 76.9% with ocular involvement).
  • Two of three ARC cases with cotton-wool spots progressed to Pneumocystis carinii pneumonia shortly after examination.
  • A significant correlation was found between ocular changes and decreased CD4+ lymphocyte levels.

Conclusions:

  • Ocular manifestations in HIV infection serve as valuable indicators of disease progression.
  • These findings are as prognostically significant as opportunistic infections or AIDS-related cancers.
  • Ophthalmological monitoring can aid in predicting the natural history of HIV infection.

Related Experiment Videos