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Published on: October 24, 2025
Marine Alkylpurines: A Promising Group of Bioactive Marine Natural Products
Pablo A García1, Elena Valles2, David Díez3
1Department of Pharmaceutical Sciences, Medicinal Chemistry Section, Pharmacy Faculty, CIETUS, IBSAL, University of Salamanca, E-37007 Salamanca, Spain. pabloagg@usal.es.
Abstract:
Marine secondary metabolites with a purine motif in their structure are presented in this review. The alkylpurines are grouped according to the size of the alkyl substituents and their location on the purine ring. Aspects related to the marine source, chemical structure and biological properties are considered together with synthetic approaches towards the natural products and bioactive analogues. This review contributes to studies of structure-activity relationships for these metabolites and highlights the potential of the sea as a source of new lead compounds in diverse therapeutic fields.
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