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Measuring Oxidative Stress Resistance of Caenorhabditis elegans in 96-well Microtiter Plates
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Programming of Cell Resistance to Genotoxic and Oxidative Stress

Ilya O Velegzhaninov1,2, Vitaly A Ievlev3, Yana I Pylina4

  • 1Institute of Biology of Komi Science Centre of Ural Branch of RAS, Syktyvkar 167982, Russia. vellio@yandex.ru.

Biomedicines
|January 6, 2018
PubMed

Insights

Organisms vary in genotoxic stress resistance due to genetic and epigenetic factors. Overexpressing stress-response genes offers potential for cancer therapy and enhancing radioresistance for space travel.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Organisms exhibit significant variation in resistance to genotoxic stress.
  • Genetic and epigenetic factors play a crucial role in regulating stress resistance.
  • Understanding stress resistance mechanisms has implications for cancer therapy, agriculture, and human radioresistance.

Purpose of the Study:

  • To review the genetic mechanisms underlying genotoxic stress resistance.
  • To analyze the possibilities and limitations of regulating stress resistance through gene overexpression.
  • To explore the potential of advanced gene overexpression technologies for future research.

Main Methods:

  • Comparative analysis of transcriptomic studies in cancer cells.
  • Systematic review and analysis of experimental data on gene overexpression and stress resistance.
  • Literature review focusing on genetic and epigenetic regulation of stress response.

Main Results:

  • A high diversity of genetic mechanisms contributes to genotoxic stress resistance.
  • Overexpression of stress-response genes can modulate resistance in cells and organisms.
  • Existing data provides a foundation for understanding the impact of gene overexpression on stress resistance.

Conclusions:

  • Genetic and epigenetic regulation offers diverse strategies for managing genotoxic stress.
  • Gene overexpression presents a viable approach to enhance cellular and organismal resistance.
  • Advances in gene editing technologies, like mutant Cas9, coupled with extensive gene function data, create new avenues for investigating stress resistance.
Keywords:
cell programmingchemical genotoxinsdiversity of mechanismsgene overexpressionmalignant transformationoxidative stressradiationstress resistance

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