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Complete Genome Sequence of Bacteriophage SM9-3Y Infecting Serratia marcescens

Yuchong Hao1, Hongyan Shi1, Jinghua Li1

  • 1Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.

Genome Announcements
|January 6, 2018
PubMed

Insights

The lytic bacteriophage SM9-3Y, targeting Serratia marcescens, has had its complete genome sequenced. This research advances bacteriophage therapy for controlling nosocomial infections caused by Serratia marcescens.

Area of Science:

  • Microbiology
  • Virology
  • Genomics

Background:

  • Serratia marcescens is a significant opportunistic pathogen responsible for hospital-acquired infections.
  • Bacteriophage therapy presents a promising alternative for managing S. marcescens infections.

Purpose of the Study:

  • To present the complete genome sequence of the lytic Serratia marcescens bacteriophage SM9-3Y.
  • To provide genomic data that can facilitate the development of phage-based therapeutic strategies.

Main Methods:

  • Whole-genome sequencing of the bacteriophage SM9-3Y.
  • Bioinformatic analysis of the resulting DNA sequence.

Main Results:

  • The complete genome sequence of bacteriophage SM9-3Y was determined.
  • The genome is a linear double-stranded DNA molecule of 39,631 base pairs.
  • The G+C content of the genome is 50.7%.

Conclusions:

  • The genomic characterization of SM9-3Y provides a foundation for its potential application in phage therapy.
  • Understanding the genetic makeup of this bacteriophage is crucial for its effective use against Serratia marcescens infections.

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