Jove
Visualize
Contact Us

Related Concept Videos

Plasticity00:58

Plasticity

3.1K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
3.1K
Plasticizers01:31

Plasticizers

379
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
379
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

1.3K
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
1.3K
Plastic Behavior01:21

Plastic Behavior

598
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
598
Plastic Deformations01:14

Plastic Deformations

487
It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
487
Plastic Deformations01:19

Plastic Deformations

480
Plastic deformation represents a fundamental concept in materials science, which explains the irreversible change in the shape of a material when it experiences stress beyond its elastic capability. This phenomenon is important in structural engineering, especially in designing and analyzing cantilever beams—structures that are securely fixed at one end and bear loads at the opposite end. When these beams are subjected to loads within their elastic range, they will return to their...
480

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered postnatal chromatin development in the nucleus accumbens primes lifelong stress sensitivity.

bioRxiv : the preprint server for biology·2025
Same author

Reduced SK channel control of mesolimbic dopamine neuron firing drives reward seeking adaptations in chronic pain.

bioRxiv : the preprint server for biology·2025
Same author

Portuguese Man O' War-induced Sural Compression Neuropathy: A Case Report.

Pain medicine case reports·2025
Same author

The role of inflammation, chronic pain, and hypertension on cognitive functioning in an underserved, rural population: a Project FRONTIER study.

Journal of clinical and experimental neuropsychology·2025
Same author

A simple action reduces high-fat diet intake and obesity in mice.

Current biology : CB·2025
Same author

A simple action reduces high fat diet intake and obesity in mice.

bioRxiv : the preprint server for biology·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 16, 2026

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.6K

Amygdala Plasticity and Pain.

Jeremy M Thompson1, Volker Neugebauer1,2

  • 1Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX, USA.

Pain Research & Management
|January 6, 2018
PubMed
Summary
This summary is machine-generated.

The amygdala, a brain region crucial for emotion and pain, becomes overactive in pain states due to impaired cortical control. This review explores mechanisms and new strategies for correcting amygdala dysfunction in pain.

More Related Videos

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
10:48

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

Published on: June 3, 2013

22.8K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.9K

Related Experiment Videos

Last Updated: Feb 16, 2026

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram
09:00

Author Spotlight: Quantifying Pain Experience – An Illustrative Approach Using the Pain Body Diagram

Published on: July 7, 2023

4.6K
How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
10:48

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

Published on: June 3, 2013

22.8K
Intracranial Pharmacotherapy and Pain Assays in Rodents
02:26

Intracranial Pharmacotherapy and Pain Assays in Rodents

Published on: April 9, 2019

5.9K

Area of Science:

  • Neuroscience
  • Pain Research
  • Emotional Processing

Background:

  • The amygdala is central to emotional processing, neuropsychiatric disorders, and the affective dimension of pain.
  • Amygdala hyperactivity and impaired cortical control are observed in pain states.
  • Basolateral amygdala (BLA) hyperactivity deactivates the medial prefrontal cortex (mPFC), causing cognitive deficits.

Purpose of the Study:

  • To review mechanisms of abnormal amygdala activity in pain.
  • To focus on the loss of cortical control mechanisms in pain plasticity.
  • To discuss novel strategies for correcting pain-related amygdala dysfunction.

Main Methods:

  • Review of preclinical and clinical studies.
  • Analysis of neural pathways involving the amygdala, mPFC, and intercalated cell mass (ITC).
  • Examination of GABAergic neuron function in amygdala output gating.

Main Results:

  • Amygdala hyperactivity in pain is linked to impaired cortical inhibition.
  • The mPFC-ITC-CeLC pathway is critical for gating amygdala output.
  • Loss of cortical control contributes to amygdala pain plasticity.

Conclusions:

  • Dysfunctional amygdala activity in pain arises from impaired cortical regulation.
  • Restoring cortical control over the amygdala is a potential therapeutic strategy.
  • Further research into these mechanisms may yield new pain treatments.