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Maternal Separation Does Not Produce a Significant Behavioral Change in Mice
Shawn Tan1,2, Hin San Ho1,2, Anna Yoonsu Song1,3
1Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, Singapore, 169857, Singapore.
Experimental Neurobiology
|January 6, 2018
Summary
Early life stress paradigms, including maternal separation (MS) and maternal separation with early weaning (MSEW), did not induce behavioral anomalies in male mice. Further validation of MS paradigms in mice is required.
Area of Science:
- Neuroscience
- Behavioral Science
- Animal Models
Background:
- Early life adversities and genetics increase neuropsychiatric disorder risk.
- Maternal separation (MS) in rats causes depression/anxiety-like behaviors.
- MS studies in mice show inconsistent behavioral outcomes.
Purpose of the Study:
- To assess behavioral outcomes of two early-life stress paradigms in mice.
- To investigate the efficacy of conventional 3-hour MS and MSEW paradigms.
- To validate MS paradigms for use in C57BL/6J male mice.
Main Methods:
- Utilized two early-life stress paradigms: conventional 3-hour MS and MSEW.
- Employed C57BL/6J male mice in independent cohorts.
- Assessed behavioral outcomes following stress paradigms.
Main Results:
- Neither the 3-hour MS nor the MSEW paradigm produced significant behavioral anomalies.
- No reported depression- or anxiety-like behaviors were observed in the stressed mice.
- The study failed to replicate previously reported behavioral outcomes in mice.
Conclusions:
- Current MS paradigms in mice require further validation and modification.
- The efficacy of MS as a model for neuropsychiatric disorders in mice is questionable.
- Replication and refinement of stress protocols are necessary for mouse models.
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