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Related Concept Videos

Elastin is Responsible for Tissue Elasticity01:12

Elastin is Responsible for Tissue Elasticity

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Elastic fiber contains the protein elastin along with lesser amounts of other proteins and glycoproteins. The main property of elastin is that it will return to its original shape after being stretched or compressed. Elastic fibers are prominent in elastic tissues found in skin and the elastic ligaments of the vertebral column.
Ligaments and tendons are made of dense regular connective tissue, but in ligaments not all fibers are parallel. Dense regular elastic tissue contains elastin fibers and...
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Elasticity01:12

Elasticity

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Elasticity is the ability of an object to withstand the effects of distortion and to return to its original size and shape once the forces causing deformation are removed. When an elastic material deforms under the action of an external force, it experiences internal resistance to the deformation. However, if no external force is applied, it returns to its original state.
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Elasticity in Concrete01:20

Elasticity in Concrete

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Upon subjecting concrete to moderate or high uniaxial compressive or tensile stresses, the strain response is non-linear relative to the stress applied. As the stress is removed, the resulting stress-strain curve deviates from the original path traced during loading, creating a hysteresis loop, indicative of the concrete's non-linear and non-elastic properties. Typically, a material's modulus of elasticity, which is a measure of the material's stiffness, is inferred from the linear...
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Elastic Potential Energy01:01

Elastic Potential Energy

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Elastic potential energy is the energy stored as a result of the deformation of an elastic object, such as the stretching of a spring. An object is elastic if it returns to its original shape and size after being deformed. 
Potential energy is also associated with the elastic force exerted by an ideal spring. The work done by this force can be represented as a change in the elastic potential energy of the spring. Thus, the work done by a perfectly elastic spring, in one dimension, depends...
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Strain and Elastic Modulus01:15

Strain and Elastic Modulus

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The quantity that describes the deformation of a body under stress is known as strain. Strain is given as a fractional change in either length, volume, or geometry under tensile, volume (also known as bulk), or shear stress, respectively, and is a dimensionless quantity. The strain experienced by a body under tensile or compressive stress is called tensile or compressive strain, respectively. In contrast, the strain experienced under bulk stress and shear stress is known as volume and shear...
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Elastic Collisions: Introduction01:00

Elastic Collisions: Introduction

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An elastic collision is one that conserves both internal kinetic energy and momentum. Internal kinetic energy is the sum of the kinetic energies of the objects in a system. Truly elastic collisions can only be achieved with subatomic particles, such as electrons striking nuclei. Macroscopic collisions can be very nearly, but not quite, elastic, as some kinetic energy is always converted into other forms of energy such as heat transfer due to friction and sound. An example of a nearly...
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Updated: Feb 16, 2026

Ultrathin Porated Elastic Hydrogels As a Biomimetic Basement Membrane for Dual Cell Culture
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Biomimetic heterogenous elastic tissue development.

Kai Jen Tsai1, Simon Dixon2, Luke Richard Hale1

  • 1Division of Surgery and Interventional Science, University College London, London, UK.

NPJ Regenerative Medicine
|January 6, 2018
PubMed
Summary
This summary is machine-generated.

Direct 3D printing offers rapid, cost-effective, acellular elastic tissue substitutes using thermoplastic polyurethanes. This innovative approach bypasses cell culture, enabling in-situ, point-of-care tissue regeneration.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • 3D Printing Technology

Background:

  • Current tissue engineering faces limitations including high costs, long maturation times, and reliance on cell culture.
  • Donor organs and autologous tissue grafts present challenges such as donor site morbidity and organ shortages.
  • There is a significant need for advanced, accessible artificial tissues for repair and replacement.

Purpose of the Study:

  • To investigate the direct 3D printing of thermoplastic polyurethanes for creating acellular, elastic tissue substitutes.
  • To demonstrate a rapid, cost-effective, and cell-independent method for producing in-situ tissue constructs.
  • To explore the potential for incorporating bioactive molecules into 3D printed constructs for enhanced therapeutic applications.

Main Methods:

  • Utilized Fused Deposition Modelling (FDM) for direct 3D printing of biocompatible thermoplastic polyurethanes.
  • Developed acellular constructs with controlled porosity to potentially support vascularization.
  • Demonstrated post-processing techniques for incorporating bioactive molecules into the printed scaffolds.
  • Fabricated tubular constructs as exemplars of elastic tissue substitute applications.

Main Results:

  • Successfully 3D printed biocompatible thermoplastic polyurethanes into elastic tissue substitutes.
  • Achieved rapid and economical production of heterogeneous, biomimetic constructs.
  • Demonstrated the ability to create constructs with controlled porosity for potential vascularization.
  • Showcased post-processing for bioactive molecule incorporation, enhancing therapeutic potential.

Conclusions:

  • Direct 3D printing of thermoplastic polyurethanes provides a viable, cell-independent strategy for creating elastic tissue substitutes.
  • This acellular approach offers a rapid, cost-effective alternative to traditional cell-based tissue engineering.
  • The technology holds promise for in-situ, point-of-care applications, potentially revolutionizing tissue repair and replacement therapies.