Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

1.2K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.2K
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

237
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
237
Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Secondary Motives: Power Motivation and Achievement Motivation01:27

Secondary Motives: Power Motivation and Achievement Motivation

587
Power motivation and achievement motivation are two essential social motives identified by psychologist David McClelland. These motives influence behavior in various personal and professional contexts, shaping how individuals interact with others and pursue their goals.
Power motivation is characterized by the desire to influence, control, or have an impact on others. It is shaped by an individual's experiences, social environment, and cultural context. People with high power motivation are...
587
Group Therapy01:26

Group Therapy

472
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
472
Behavior Therapy01:22

Behavior Therapy

758
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
758

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription.

Science (New York, N.Y.)·2026
Same author

Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance.

Science advances·2026
Same author

Nuclear proteome reveals microtubule-associated protein regulating fate and disease.

Cell·2026
Same author

Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3.

Neuron·2026
Same author

Wrap it up: myelination of transplanted neurons for repair.

Frontiers in cellular neuroscience·2025
Same author

Astrocyte diversity and subtypes: aligning transcriptomics with multimodal perspectives.

EMBO reports·2025

Related Experiment Video

Updated: Feb 16, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

10.1K

Neuronal replacement therapy: previous achievements and challenges ahead.

Sofia Grade1,2, Magdalena Götz1,2,3

  • 1Physiological Genomics, Biomedical Center, Ludwig-Maximilians University Munich, 82152 Planegg-Martinsried, Germany.

NPJ Regenerative Medicine
|January 6, 2018
PubMed
Summary

Brain repair strategies face challenges in integrating new neurons into existing circuits. Understanding neural connectivity is crucial for successful regenerative medicine and restoring brain function after injury.

More Related Videos

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
07:52

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

9.3K
Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
09:34

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy

Published on: May 18, 2017

8.0K

Related Experiment Videos

Last Updated: Feb 16, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

10.1K
Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
07:52

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

9.3K
Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy
09:34

Preparation of Plasma Membrane Vesicles from Bone Marrow Mesenchymal Stem Cells for Potential Cytoplasm Replacement Therapy

Published on: May 18, 2017

8.0K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Mammalian brains exhibit lifelong neurogenesis in specific areas, serving as a model for neuronal replacement.
  • The plasticity of brain regions lacking adult neurogenesis for accommodating new neurons after injury remains a key question.
  • Restoring function and ensuring proper integration of replaced neurons into existing circuitry are critical challenges.

Purpose of the Study:

  • To review advances in neuronal replacement strategies using exogenous and endogenous cell sources.
  • To explore the critical role of neural circuitry and connectivity in the success of brain repair.
  • To highlight the importance of understanding microenvironments and cell types for permissive neuronal integration.

Main Methods:

  • Discussion of novel technologies such as induced pluripotent stem cells and direct neuronal reprogramming.
  • Analysis of existing research on neuronal replacement and integration strategies.
  • Review of studies investigating the functional and structural integration of transplanted or reprogrammed neurons.

Main Results:

  • Significant progress has been made in neuronal replacement strategies, including stem cell therapies and direct reprogramming.
  • Induced pluripotent stem cells and direct neuronal reprogramming offer promising alternatives to fetal neuron transplantation.
  • The integration and functional participation of newly incorporated neurons within complex neural networks are still under investigation.

Conclusions:

  • Neuronal circuitry analysis is paramount for the future success of regenerative medicine in the brain.
  • Achieving functional restoration requires new neurons to integrate properly into brain-wide networks, maintaining appropriate input and output.
  • Integrating neural circuitry research into regenerative medicine is essential for effectively repairing brain injury.