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Updated: Feb 16, 2026

The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells
Published on: November 20, 2017
The malignant niche: safe spaces for toxic stem cell marketing
Douglas Sipp1,2,3,4
1RIKEN Center for Developmental Biology, Kobe, Japan.
Abstract:
Many tumors are sustained by microenvironments, or niches, that support and protect malignant cells, thus conferring a competitive advantage against both healthy cells and therapeutic interventions (for a brief review, see Yao and Link (Stem Cells 35: 3-8, 2017)). The global industry engaged in the commercial promotion of unproven and scientifically implausible cell-based "regenerative" therapies has developed a number of self-protective strategies that support its survival and growth in ways that are broadly analogous to the functions of the malignant niche.
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