Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Base Excision Repair

Base Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

Stages of Infection

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Predictors of impaired quality of life among colorectal cancer survivors: a cross-sectional study.

Journal of patient-reported outcomes·2025

Same author

First report: International proctoring of robotic colorectal surgery using TELEPRO<sup>®</sup>.

Surgery today·2025

Same author

Sphincter-Preserving Robotic Surgery for Rectal Cancer Anteriorly Invading Rectourethralis Muscle: Intersphincteric Resection With En-Bloc Prostatectomy.

Diseases of the colon and rectum·2025

Same author

Robotic beyond total mesorectal excision for locally advanced rectal cancers: Perioperative and oncological outcomes from a multicentre case series.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2024

Same author

International standardization and optimization group for intersphincteric resection (ISOG-ISR): modified Delphi consensus on anatomy, definition, indication, surgical technique, specimen description and functional outcome.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2023

Same author

Treatment of side limb full-thickness prolapse of the side-to-end coloanal anastomosis following intersphincteric resection: a case report and review of literature.

Annals of coloproctology·2023

Search research articles

Related Experiment Video

Updated: Feb 16, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Single stage robotic total mesorectal excision-a stepwise approach.

Eko Priatno¹, Seon Hahn Kim²

¹Department of Surgery, Puri Indah Hospital, Jakarta, Indonesia.

Journal of Visualized Surgery

|January 6, 2018

Summary

This study demonstrates that single-stage robotic total mesorectal excision (TME) is an effective surgical approach for mid-rectal cancer. The procedure offers a feasible and efficient option for patients requiring this type of minimally invasive surgery.

Keywords:

Robotics robotic TME total mesorectal excision (TME)

More Related Videos

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Feb 16, 2026

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

Published on: February 7, 2025

Area of Science:

Surgical Oncology
Minimally Invasive Surgery
Robotic Surgery

Background:

Traditional robotic total mesorectal excision (TME) involves two or three stages.
Robotic surgery offers potential benefits for complex procedures like TME.
This video details a stepwise approach to robotic TME for mid-rectal cancer.

Purpose of the Study:

To present a video demonstration of a single-stage robotic TME procedure.
To evaluate the feasibility and efficiency of this technique for mid-rectal cancer.

Main Methods:

A da Vinci Si HD Surgical System was utilized for the procedure.
The surgery involved three distinct phases: abdominal, pelvic dissection, and rectal reconstruction.
The procedure was completed using a single-stage robotic approach, with remaining steps performed laparoscopically.

Main Results:

Robotic TME was successfully performed on a 56-year-old male patient with moderately differentiated adenocarcinoma.
The operative time was 160 minutes, and the patient was discharged on postoperative day 10.
Final pathology confirmed moderately differentiated adenocarcinoma.

Conclusions:

Single-stage robotic TME is an efficient and feasible technique for mid-rectal cancer resection.
This approach may offer advantages in managing mid-rectal tumors.