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Helicobacter pylori Infection and Risk Factors in Relation to Allergy in Children

Ilva Daugule1, Daiga Karklina1,2, Silvija Remberga1,2

  • 1Faculty of Medicine, University of Latvia, Riga, Latvia.

Pediatric Gastroenterology, Hepatology & Nutrition
|January 6, 2018
PubMed

Insights

Helicobacter pylori infection prevalence did not differ between allergic and non-allergic children. Factors like C-section delivery and antibiotic use may influence allergy development, alongside genetic predisposition.

Area of Science:

  • Pediatric Allergy and Immunology
  • Microbiology
  • Environmental Health

Background:

  • The relationship between Helicobacter pylori infection and allergic diseases in children remains incompletely understood.
  • Investigating environmental factors associated with allergy is crucial for understanding disease etiology.

Purpose of the Study:

  • To determine the prevalence of Helicobacter pylori infection in children with and without allergies.
  • To identify environmental risk factors associated with allergy development in pediatric populations.

Main Methods:

  • A cross-sectional study involving 220 children, comparing those with and without allergies.
  • Data collection included parental questionnaires and stool samples for H. pylori antigen testing.
  • Statistical analyses utilized chi-squared tests, ANOVA, and logistic regression.

Main Results:

  • No significant difference in H. pylori positivity was observed between allergic (13.9%) and non-allergic (22.4%) children (p=0.106).
  • Allergy was significantly associated with a family history of allergy (OR, 8.038), Caesarean section delivery (OR, 2.980), exclusive breastfeeding for 5 months (OR, 2.601), and recent antibacterial treatment (OR, 2.381).

Conclusions:

  • Helicobacter pylori infection prevalence does not differ significantly between allergic and non-allergic children.
  • Factors such as Caesarean section delivery and antibacterial therapy suggest a potential role for gut microbiota in allergy development.
  • Genetic factors, indicated by a family history of allergy, remain a significant contributor to allergy etiology.
Abstract

Keywords:
AllergyHelicobacter pyloriRisk factors

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