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Severe hyponatremia associated with escitalopram
Gautam Rawal1, Raj Kumar1, Sankalp Yadav2
1Department of Respiratory Intensive Care, Max Super Specialty Hospital, Saket, New Delhi, India.
Journal of Family Medicine and Primary Care
|January 6, 2018
Summary
Selective serotonin reuptake inhibitors (SSRIs) can cause hyponatremia, a dangerous drop in sodium levels. This case highlights escitalopram-induced SIADH, emphasizing cautious use and electrolyte monitoring in depressed patients.
Area of Science:
- Neuroscience
- Endocrinology
- Pharmacology
Background:
- Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for depression.
- Hyponatremia, a rare complication, can occur during SSRI therapy.
- Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is a known cause of hyponatremia.
Observation:
- A 54-year-old female with hypertension presented with a seizure episode.
- The patient was recently prescribed escitalopram for depression.
- Severe hyponatremia was diagnosed, attributed to SSRI-induced SIADH.
Findings:
- Escitalopram, an SSRI, was identified as the causative agent for SIADH.
- The patient's hyponatremia was a direct result of escitalopram intake.
- This case adds to the limited reports of escitalopram-induced SIADH.
Implications:
- All SSRIs, including escitalopram, carry a risk of causing SIADH.
- Caution is advised when prescribing SSRIs, particularly escitalopram.
- Regular electrolyte monitoring is crucial in patients on SSRIs, especially the elderly.
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