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Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
Published on: August 10, 2016
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Enhanced dissolution of ibuprofen using ionic liquids as catanionic hydrotropes.
T E Sintra1, K Shimizu, S P M Ventura
1CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jcoutinho@ua.pt.
Physical Chemistry Chemical Physics : PCCP
|January 6, 2018
Summary
Ionic liquids significantly enhance ibuprofen solubility, acting as potent hydrotropes. Specific ionic liquids like [C4C1im][SCN] and [C4C1im][N(CN)2] show remarkable solubilization capabilities.
Area of Science:
- Pharmaceutical Science
- Physical Chemistry
- Materials Science
Background:
- Drug bioavailability is critically dependent on aqueous solubility.
- Hydrotropes enhance solubility of hydrophobic substances, crucial for drug and personal care product formulation.
- Ionic liquids are emerging as effective hydrotropes for biomolecules.
Purpose of the Study:
- To evaluate the impact of ionic liquid structure and concentration on ibuprofen solubility.
- To compare the hydrotropic performance of ionic liquids with conventional hydrotropes.
- To elucidate the mechanism behind ionic liquid-mediated drug solubilization.
Main Methods:
- Systematic evaluation of various ionic liquids and their concentrations.
- Comparison with established hydrotropic agents.
- Investigation of solubilization mechanisms using dynamic light scattering and molecular dynamics simulations.
Main Results:
- Ionic liquids demonstrate exceptional capacity to enhance ibuprofen solubility.
- Increases in ibuprofen solubility of 60- and 120-fold were achieved with [C4C1im][SCN] and [C4C1im][N(CN)2] respectively, at ~1 mol kg-1 concentrations.
- Mechanism involves the structure of ionic liquid aqueous solutions and the formation of ionic liquid-drug aggregates.
Conclusions:
- Ionic liquids are highly effective hydrotropes for improving drug solubility.
- Specific ionic liquids show significant potential for pharmaceutical formulations.
- Understanding the solution structure and aggregation is key to IL-mediated hydrotropy.
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