A Review on Pityriasis Rubra Pilaris.

Area of Science:

• Dermatology
• Genetics
• Immunology

Background:

• Pityriasis rubra pilaris (PRP) is an idiopathic papulosquamous dermatosis.
• Characterized by hyperkeratotic follicular papules, scaly plaques, and palmoplantar keratoderma.
• Classified into six subtypes, with subtype VI associated with HIV.

Purpose of the Study:

• To review the clinicopathologic features, pathogenesis, and associated disorders of PRP.
• To critically appraise the existing literature on PRP treatment.
• To emphasize recent advancements in PRP therapy.

Main Methods:

• Literature review of clinicopathologic features, pathogenesis, and treatment of PRP.
• Analysis of Griffiths' classification for PRP subtypes.
• Evaluation of evidence for various therapeutic regimens, including retinoids and biologics.

Main Results:

• PRP presents with distinct clinical features and can be subtyped.
• CARD14 gene mutations are implicated in familial PRP.
• Treatment remains challenging, with oral retinoids as a mainstay and biologics showing promise.

Conclusions:

• Understanding PRP subtypes and associations is crucial for diagnosis and management.
• Further research is needed to establish high-quality evidence for optimal treatment.
• Biologics represent a significant advancement in managing recalcitrant PRP.