Related Experiment Video For neutrophils
Updated: Feb 16, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Propolis increases neutrophils response against Candida albicans through the increase of reactive oxygen species
Nayara Cristina Alves de Lima1, Bianca Altrao Ratti1, Patrícia de Souza Bonfim Mendonça2
1Bioscience & Physiopathology Graduate Program, Universidade Estadual de Maringá (UEM), Av Colombo 5790, 87025-210 Maringá, PR, Brazil.
Aim:
To investigate whether Brazilian green propolis improves the immune response against recurrent form isolate recurrent vulvovaginal candidiasis (RVVC) caused by Candida albicans by increasing neutrophil oxidative burst.
Materials & Methods:
We evaluated oxidant species production, oxygen consumption, microbicidal activity and myeloperoxidase activity in neutrophils previously treated with propolis and activated with different isolates of C. albicans (RVVC), vulvovaginal candidiasis, asymptomatic isolates and the reference strain.
Results:
Propolis significantly increased oxidant species production, oxygen consumption, microbicidal activity and myeloperoxidase activity of neutrophils against different isolates of C. albicans including RVVC isolate that are considered resistant to the microbicidal activity of neutrophils.
Conclusion:
Brazilian green propolis may increase neutrophil burst oxidative response to RVVC leading to an efficient removal of C. albicans.
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