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Dyslipidaemia in the elderly: to treat or not to treat?

Niki Katsiki1, Genovefa Kolovou2, Pablo Perez-Martinez3

  • 1a Second Propedeutic Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, Hippocration Hospital , Thessaloniki , Greece.

Expert Review of Clinical Pharmacology
|January 6, 2018
PubMed

Insights

Older adults face increased cardiovascular disease (CVD) risk due to factors like dyslipidemia. Lipid-lowering therapies and lifestyle changes are crucial for managing CVD risk in the elderly, with individualized treatment plans being key.

Area of Science:

  • Gerontology
  • Cardiology
  • Pharmacology

Background:

  • The global elderly population is growing, leading to a higher prevalence of cardiovascular disease (CVD).
  • Advancing age is linked to increased incidence of CVD risk factors, including type 2 diabetes mellitus, hypertension, and dyslipidemia.
  • These age-related risk factors contribute to a substantially higher absolute CVD risk in older individuals.

Purpose of the Study:

  • To review the association between dyslipidemia and CVD in the elderly.
  • To evaluate the impact of lifestyle interventions and lipid-lowering drugs on lipid profiles and CVD risk in older adults.
  • To discuss individualized treatment goals, therapeutic options, and special considerations for drug therapy efficacy and safety in the elderly.

Main Methods:

  • This study is a narrative review of existing literature.
  • It synthesizes information on dyslipidemia, CVD risk factors, and treatment strategies in the elderly population.
  • Current guidelines for lipid management and pharmacotherapy are examined.

Main Results:

  • Dyslipidemia is a significant contributor to cardiovascular disease (CVD) risk in the elderly.
  • Lifestyle modifications and lipid-lowering medications can effectively manage lipid levels and reduce CVD risk in older individuals.
  • Older patients may experience greater CVD benefits from drug therapy compared to younger populations.

Conclusions:

  • Individualized treatment goals and therapeutic options, guided by current guidelines, are essential for managing dyslipidemia in the elderly.
  • Special characteristics of the elderly population must be considered to optimize the efficacy and safety of hypolipidemic pharmacotherapy.
  • Tailored treatment approaches are crucial for mitigating CVD risk in this demographic.
Abstract

Keywords:
Dyslipidaemiacardiovascular riskelderlyguidelineslipid-lowering drugsstatins

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