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Updated: Feb 16, 2026

Digital Microfluidics for Automated Proteomic Processing
Published on: November 6, 2009
[A boy with digital clubbing]
1Maastricht Universitair Medisch Centrum+, afd. Kindergeneeskunde, Maastricht.
Abstract:
A 4-year-old boy was referred because of pan-digital clubbing and watch-glass nails. Other remarkable findings were: surgical closure of a patent arterial duct, decreased knee-mobility and consanguineous parents. This combination is suggestive for primary hypertrophic osteoarthropathy (PHO; #OMIM 259100). PHO was proven by his homozygous mutation of the 15-hydroxyprostaglandine dehydroxygenase-gene.
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