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[Testosterone therapy: indications and risks].

M G F Maatje1, M Dinkelman-Smit, W P A Boellaard

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Summary
This summary is machine-generated.

Late onset hypogonadism (LOH) in men is a testosterone shortage causing symptoms like low libido and fatigue. Diagnosis is confirmed with testosterone levels below 8 nmol/l alongside symptoms, with lifestyle changes and testosterone therapy being key treatments.

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Area of Science:

  • Endocrinology
  • Andrology
  • Men's Health

Background:

  • Late onset hypogonadism (LOH) is characterized by a decline in testosterone levels in adult men.
  • Symptoms are often non-specific, mimicking aspects of aging, including reduced libido, strength, cognitive function, and mood disturbances.

Purpose of the Study:

  • To define diagnostic criteria for LOH.
  • To outline management strategies, including lifestyle modifications and testosterone replacement therapy.
  • To highlight the benefits and contraindications of testosterone therapy.

Main Methods:

  • Clinical assessment of symptoms consistent with LOH.
  • Measurement of serum testosterone levels (diagnosis indicated if < 8 nmol/l).
  • Evaluation of comorbidities and lifestyle factors.

Main Results:

  • Testosterone therapy positively impacts sexual function and vitality.
  • Testosterone therapy reduces the risk of osteoporosis in hypogonadal men.
  • Contraindications include advanced prostate cancer and desire for fertility.

Conclusions:

  • LOH diagnosis is based on clinical symptoms and confirmed testosterone levels.
  • Management involves lifestyle changes, comorbidity treatment, and potentially testosterone therapy.
  • Close monitoring of testosterone, haematocrit, and PSA levels is crucial during therapy.