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Cell-free DNA as a biomarker in stroke: Current status, problems and perspectives
Kristina V Glebova1, Natalya N Veiko1, Aleksey A Nikonov2
1a Laboratory of Molecular Biology , Federal State Budgetary Institution "Research Centre for Medical Genetics" , Moscow , Russia.
Critical Reviews in Clinical Laboratory Sciences
|January 6, 2018
Summary
Cell-free DNA (cfDNA) shows promise as a stroke biomarker. Dynamic blood cfDNA levels may offer prognostic insights into stroke severity and outcomes, despite current limitations.
Area of Science:
- Biomarkers
- Neuroscience
- Molecular Biology
Background:
- No universally accepted stroke biomarker exists for clinical use.
- Cell-free DNA (cfDNA) circulating in biological fluids during stroke is under investigation.
- cfDNA holds potential as a novel biomarker for stroke diagnosis and prognosis.
Purpose of the Study:
- To review the potential of cfDNA as a stroke biomarker.
- To examine evidence from animal and clinical studies.
- To discuss cfDNA analysis protocols and origins.
Main Methods:
- Literature review of animal models and clinical studies on cfDNA in stroke.
- Analysis of existing data on cfDNA levels and stroke outcomes.
- Examination of proposed cfDNA detection and quantification methods.
Main Results:
- Dynamically measured blood cfDNA levels may offer prognostic information for stroke severity and outcomes.
- Evidence from both preclinical and clinical studies supports cfDNA's potential.
- Various protocols exist for cfDNA analysis, each with specific considerations.
Conclusions:
- cfDNA represents a promising, yet not fully established, biomarker for stroke.
- Further research is needed to overcome limitations and standardize cfDNA analysis for clinical application.
- Understanding cfDNA origins is crucial for refining its role in stroke management.
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