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Mandibular Osteonecrosis Associated With Raloxifene.

Hélder Antônio Rebelo Pontes1, Lucas Lacerda de Souza, Daniel Cavalléro Colares Uchôa

  • 1João de Barros Barreto University Hospital, Federal University of Pará, Pará, Brazil.

The Journal of Craniofacial Surgery
|January 6, 2018
PubMed
Summary

Raloxifene, a medication for bone metabolism, has been linked to a few cases of jaw osteonecrosis. This report details a patient experiencing mandibular osteonecrosis while continuing raloxifene treatment.

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Area of Science:

  • Oral surgery
  • Pharmacology
  • Bone metabolism

Background:

  • Osteonecrosis is a complex condition affecting bone viability.
  • Medications for systemic bone metabolism issues can sometimes cause osteonecrosis.
  • Raloxifene is a medication used for bone health.

Observation:

  • A 64-year-old woman presented with a focal area of necrosis.
  • The necrosis was located in the right alveolar ridge of the mandible.
  • The patient had been continuously using raloxifene.

Findings:

  • This case report documents osteonecrosis of the jaw (ONJ).
  • The mandibular osteonecrosis was associated with ongoing raloxifene therapy.
  • This highlights a potential adverse effect of raloxifene on jaw bone health.

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Implications:

  • Clinicians should consider raloxifene as a potential factor in jaw osteonecrosis.
  • Further investigation into raloxifene's role in ONJ is warranted.
  • This case contributes to understanding medication-related osteonecrosis of the jaw.