Related Experiment Video
Updated: Feb 16, 2026
08:39
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
5.5K
Metabolomics technology and bioinformatics for precision medicine
Briefings in Bioinformatics
|January 6, 2018
Summary
Precision medicine uses metabolomics to personalize patient treatment. This review covers metabolomics technologies and bioinformatics for tailored medical strategies, despite current limitations.
Area of Science:
- Biochemistry
- Bioinformatics
- Systems Biology
Background:
- Precision medicine aims to customize treatments based on individual genetic, environmental, and lifestyle factors.
- Metabolomics, a key omics discipline, is crucial for understanding patient metabolic states.
Purpose of the Study:
- To review metabolomics technologies and bioinformatics approaches for precision medicine.
- To highlight the power of metabolomics in patient stratification and treatment monitoring.
Main Methods:
- Review of metabolomics data generation techniques.
- Analysis of bioinformatics tools for metabolomic data.
- Exploration of mathematical modeling and data fusion in metabolomics.
- Discussion of data management strategies.
Main Results:
- Metabolomics provides a metabolic snapshot for disease and treatment monitoring.
- Integration with bioinformatics and modeling enables patient subpopulation classification.
- Identified limitations in current metabolomics technology and bioinformatics.
Conclusions:
- Metabolomics is a powerful tool in precision medicine.
- Addressing technological and bioinformatics challenges is essential for advancing metabolomics applications.
- Further development is needed for comprehensive data integration and analysis.
Keywords:
GC-MS; LC-MSNMRbioinformaticsmass spectrometrymetabolite profilingmetabolomicsprecision medicineMore Related Videos
08:02Visualization of Metabolites Identified in the Spatial Metabolome of Traditional Chinese Medicine Using DESI-MSI
Published on: December 16, 2022
2.4K
11:06Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
2.8K
Related Concept Videos
03:37Uncertainty in Measurement: Accuracy and Precision
106.0K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.
106.0K
01:29Microorganisms in Medicine and Therapeutics
1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
01:31Hybridoma Technology
17.8K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
17.8K
01:52Accuracy and Precision
15.9K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Highly accurate...
15.9K
02:50Combination Therapies and Personalized Medicine
6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
01:27The Precise Definition of a Limit
333
Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
333