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Tolerability profile of the current antifungal armoury

Ahmad Mourad1, John R Perfect1

  • 1Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

The Journal of Antimicrobial Chemotherapy
|January 6, 2018
PubMed

Insights

Antifungal drug tolerability is key for treating invasive fungal infections. This review details common toxicities and drug interactions of antifungal agents, offering clinical context for managing adverse events in vulnerable patients.

Area of Science:

  • Medical Mycology
  • Clinical Pharmacology

Background:

  • Invasive mycoses require effective antifungal therapy.
  • Available antifungal agents possess significant toxicities and drug-drug interaction potential.
  • Optimizing antifungal treatment outcomes necessitates understanding drug tolerability.

Purpose of the Study:

  • To review common toxicities associated with antifungal agents.
  • To identify challenges related to adverse events of antifungals.
  • To provide clinical context for antifungal-related adverse events in patients with invasive mycoses.

Main Methods:

  • Literature review of antifungal agents.
  • Analysis of reported toxicities and adverse events.
  • Clinical context assessment for patient populations.

Main Results:

  • Antifungal agents present a range of direct toxicities.
  • Drug-drug interactions are a significant concern with many antifungals.
  • Adverse events impact treatment outcomes in immunocompromised patients.

Conclusions:

  • Understanding antifungal toxicities is crucial for effective management of invasive mycoses.
  • Clinical vigilance for adverse events and drug interactions is essential.
  • Contextualizing risks aids in optimizing antifungal therapy selection and use.

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