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Prognostic Value of Free Triiodothyronine Level in Patients With Hypertrophic Obstructive Cardiomyopathy

Kuo Zhang1, Xiangbin Meng2, Wenyao Wang1

  • 1Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

The Journal of Clinical Endocrinology and Metabolism
|January 6, 2018
PubMed

Insights

Thyroid hormone levels, specifically free triiodothyronine (FT3), predict adverse events in hypertrophic obstructive cardiomyopathy (HOCM) patients. Lower FT3 levels are linked to increased mortality and transplantation risk, highlighting the need for thyroid monitoring.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Thyroid hormone is crucial for cardiovascular homeostasis, especially in disease states.
  • Hypertrophic obstructive cardiomyopathy (HOCM) is a condition where cardiac function is impaired.

Purpose of the Study:

  • To investigate if thyroid hormone levels, specifically free triiodothyronine (FT3), can independently predict adverse outcomes in patients with HOCM.
  • To assess the correlation between FT3 levels and cardiac function parameters.

Main Methods:

  • A cohort of 965 HOCM patients was analyzed, with 756 completing thyroid function tests.
  • Patients were stratified into three groups based on FT3 tertiles.
  • Outcomes, including all-cause mortality and cardiac transplantation, were tracked over a median of 44 months.

Main Results:

  • FT3 levels positively correlated with left ventricular ejection fraction.
  • Adverse event rates were significantly higher in the lowest FT3 tertile (13.4%) compared to the highest (1.2%).
  • Adjusted Cox analysis confirmed FT3 as an independent predictor of adverse events (HR 0.216, P=0.002).

Conclusions:

  • Free triiodothyronine (FT3) is a significant independent predictor of adverse events, including mortality and cardiac transplantation, in HOCM patients.
  • Thyroid function monitoring is essential for managing patients with HOCM.
  • FT3 levels correlate with cardiac function, suggesting a role in disease pathophysiology.
Abstract

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