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MicroRNA-30c functions as a tumor suppressor via targeting SNAI1 in esophageal squamous cell carcinoma

Teng Ma1, Ye Zhao2, Qitong Lu1

  • 1Department of Cardiothoracic Surgery, Zhongda Hospital, Southeast University, Nanjing 210009, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 6, 2018
PubMed
Abstract

Insights

MicroRNA-30c (miR-30c) is significantly downregulated in esophageal squamous cell carcinoma (ESCC), correlating with poor survival. Restoring miR-30c inhibits ESCC progression and metastasis by targeting SNAI1.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) play crucial roles in cancer development.
  • Aberrant miRNA expression is implicated in tumor initiation, progression, and metastasis.
  • miR-30c's role in esophageal squamous cell carcinoma (ESCC) remained largely unexplored.

Purpose of the Study:

  • To investigate the expression and function of miR-30c in ESCC.
  • To determine the relationship between miR-30c levels and patient survival.
  • To elucidate the molecular mechanism underlying miR-30c's action in ESCC.

Main Methods:

  • Expression analysis of miR-30c in ESCC tissues and serum.
  • In vitro experiments assessing the impact of miR-30c on ESCC cell proliferation, migration, and invasion.
  • Dual-luciferase reporter and Western blot assays to identify miR-30c targets.

Main Results:

  • miR-30c was significantly downregulated in ESCC tissues and cell lines.
  • Lower miR-30c expression correlated with advanced ESCC progression and poorer survival.
  • Ectopic miR-30c expression suppressed ESCC cell proliferation, invasion, and epithelial-to-mesenchymal transition (EMT).
  • miR-30c directly targets SNAI1, inhibiting ESCC progression and EMT.

Conclusions:

  • miR-30c acts as a tumor suppressor in ESCC.
  • miR-30c inhibits ESCC cell proliferation, invasion, and EMT by targeting SNAI1.
  • miR-30c represents a potential diagnostic biomarker and therapeutic target for ESCC.
Keywords:
EMTESCCmiR-30c

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