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Characteristics of butanol metabolism in alcohol dehydrogenase-deficient deermice
J A Alderman1, S Kato, C S Lieber
1Alcohol Research and Treatment Center, Bronx VA Medical Center, NY.
The Biochemical Journal
|January 15, 1989
Abstract:
Deermice lacking the low-Km alcohol dehydrogenase eliminated butan-1-ol, a substrate for microsomal oxidation but not for catalase, at 117 mumol/min per kg body wt. Microsomal fractions and hepatocytes metabolized butan-1-ol also (Vmax. = 6.7 nmol/min per nmol of cytochrome P-450, Km = 0.85 mM; Vmax. = 5.3 nmol/min per 10(6) cells, Km = 0.71 mM respectively). These results are consistent with alcohol oxidation by the microsomal system in these deermice.