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Related Experiment Video

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Revisiting the link between cognitive decline and masticatory dysfunction.

Chia-Shu Lin1

  • 1Department of Dentistry, School of Dentistry, National Yang-Ming University, No. 155, Sec. 2, Linong Street, Taipei, 11221, Taiwan. winzlin@ym.edu.tw.

BMC Geriatrics
|January 7, 2018
PubMed
Summary
This summary is machine-generated.

Tooth loss may be linked to cognitive decline, but current evidence needs careful interpretation. Future research should focus on brain imaging to understand the brain-stomatognathic axis and its role in aging.

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Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Dental Science

Background:

  • Age-related cognitive decline and dementia pose significant healthcare challenges.
  • Emerging evidence suggests a potential link between tooth loss and cognitive function decline.
  • The role of the brain-stomatognathic axis in cognitive health is under investigation.

Purpose of the Study:

  • To critically evaluate the hypothesis linking cognitive decline with masticatory dysfunction.
  • To explore the potential of brain neuroimaging in understanding the brain-stomatognathic axis.
  • To identify future research directions for studying mastication's impact on cognition.

Main Methods:

  • Review of clinical, epidemiological, and animal research published in the last five years.
  • Analysis of cross-sectional and prospective study limitations.
  • Discussion of potential brain neuroimaging applications and theoretical models.

Main Results:

  • Existing clinical and epidemiological studies often lack longitudinal data and control for confounding factors.
  • Animal studies show hippocampal deficits but may not fully represent human conditions.
  • Brain neuroimaging offers a promising approach to clarify the brain-stomatognathic network.

Conclusions:

  • The association between cognitive decline and masticatory dysfunction requires cautious interpretation due to methodological limitations.
  • Future research should employ refined behavioral assessments and control for baseline conditions.
  • Brain imaging can elucidate mastication's role in cognitive-affective processing and aging.