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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Safety Outcomes for Autologous Stem Cell Transplant in Multiple Myeloma
Morie A Gertz1, Francis K Buadi2, Suzanne R Hayman3
1Department of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN.
Mayo Clinic Proceedings
|January 7, 2018
Insights
Mayo Clinic
Area of Science:
- Hematology
- Oncology
- Transplantation Medicine
Background:
- The Mayo Clinic Stem Cell Transplantation program implemented new systems to decrease day-100 all-cause mortality.
- Reducing mortality is a key objective in stem cell transplantation protocols.
Observation:
- The program has successfully reduced day-100 all-cause mortality to 0.3%.
- A significant portion of patients (median 0 days) can now undergo stem cell transplantation as outpatients.
- Only 25% of patients require hospitalization for 5 days or more.
Findings:
- Outpatient stem cell transplantation is a safe and effective approach.
- This model significantly reduces patient-incurred costs associated with hospitalization.
Implications:
- The findings suggest a paradigm shift towards outpatient stem cell transplantation.
- This approach enhances patient accessibility and financial feasibility for transplantation.
- Further research can explore long-term outcomes and broader applicability.
Abstract:
Systems have been put in place in the Mayo Clinic Stem Cell Transplantation program to reduce day-100 all-cause mortality. Currently our mortality has been reduced to 0.3%. Patients can undergo transplant as an outpatient, with a median hospital duration of 0 days and only 25% of patients requiring a hospital stay of 5 days or greater. Outpatient transplantation is safe and reduces patient-incurred costs.
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