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Updated: Feb 16, 2026

Measuring Neuromuscular Junction Functionality
Published on: August 6, 2017
The Composition, Development, and Regeneration of Neuromuscular Junctions
Wenxuan Liu1, Joe V Chakkalakal2
1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, United States.
Abstract:
The neuromuscular junction (NMJ) is the specialized site that connects the terminal of a motor neuron axon to skeletal muscle. As a synapse NMJ integrity is essential for transducing motor neuron signals that initiate skeletal muscle contraction. Many diseases and skeletal muscle aging are linked to impaired NMJ function and the associated muscle wasting. In this chapter we review the components of an NMJ and, the processes of NMJ development, maturation, and regeneration. Also, we briefly discuss the cellular and molecular mechanisms of NMJ decline in the context of disease and aging.
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