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Updated: Feb 16, 2026

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest
Published on: April 14, 2023
Cardiac arrest during pregnancy: ongoing clinical conundrum
Carolyn M Zelop1, Sharon Einav2, Jill M Mhyre3
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Valley Hospital, Ridgewood, NJ; Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY.
Maternal cardiac arrest management requires specialized protocols, including left lateral uterine displacement and timely perimortem delivery. Addressing knowledge gaps is crucial for improving maternal resuscitation outcomes.
Area of Science:
- Obstetrics and Gynecology
- Emergency Medicine
- Cardiology
Background:
- Maternal mortality is rising in the US despite global decreases.
- Complex factors include socioeconomic issues, healthcare access, disparities, comorbidities, and ascertainment bias.
- Clinician preparedness for maternal cardiac arrest is critical.
Purpose of the Study:
- To outline essential components of maternal cardiac arrest management.
- To highlight the need for specialized interventions beyond standard resuscitation.
- To identify areas for future research in maternal resuscitation.
Main Methods:
- Review of current guidelines and best practices for maternal cardiac arrest.
- Emphasis on interdisciplinary team approach and understanding pregnancy physiology.
- Integration of standard basic and advanced cardiac life support with pregnancy-specific maneuvers.
Main Results:
- Management requires addressing aortocaval compression via left lateral uterine displacement.
- Perimortem delivery is indicated if circulation is not restored within 4 minutes in advanced pregnancy.
- Additional interventions like cardiopulmonary bypass may be necessary.
Conclusions:
- Maternal cardiac arrest necessitates a tailored approach, deviating from nonpregnant protocols.
- Simulation and team training are vital for institutional readiness.
- Further research is needed to optimize specific interventions and establish a comprehensive database.
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10:55A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
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10:25Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury
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