Related Experiment Video
Updated: Feb 16, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
20.7K
The Hippo pathway in normal development and cancer.
Marcello Maugeri-Saccà1, Ruggero De Maria2
1Division of Medical Oncology 2, "Regina Elena" National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.
Pharmacology & Therapeutics
|January 7, 2018
Summary
The Hippo pathway regulates organ size and is crucial for tissue repair. Dysregulation of YAP/TAZ proteins in this pathway is linked to cancer, offering potential therapeutic targets.
Area of Science:
- Cell Biology
- Molecular Biology
- Oncology
Background:
- The Hippo pathway is a key regulator of organ size and tissue homeostasis.
- It involves kinases and adaptor proteins that control YAP/TAZ transcription co-activators.
- The pathway integrates diverse signals, including mechanical cues and G-protein-coupled receptor ligands.
Purpose of the Study:
- To explore the multifaceted roles of the Hippo pathway in development, tissue repair, and cancer.
- To investigate the connection between YAP/TAZ activation and malignant traits.
- To identify potential therapeutic strategies targeting the Hippo pathway in cancer.
Main Methods:
- Review of existing literature on Hippo pathway signaling.
- Analysis of the role of YAP/TAZ in developmental and homeostatic processes.
- Examination of Hippo pathway involvement in tumor progression and therapeutic resistance.
Main Results:
- The Hippo pathway's complex regulation involves signals bypassing core kinase modules.
- YAP/TAZ activation is implicated in cancer development, promoting malignancy and stem cell maintenance.
- Hippo pathway dysregulation is associated with therapeutic resistance and distant metastasis.
Conclusions:
- The Hippo pathway is a critical player in development, repair, and cancer.
- Targeting YAP/TAZ offers a promising avenue for cancer therapy, with drug repositioning showing potential.
- Further research into Hippo-related biomarkers is essential for prognostic and predictive applications.
More Related Videos
Related Concept Videos
01:11Normal Distribution
17.4K
The normal, a continuous distribution, is the most important of all the distributions. Its graph is a bell-shaped symmetrical curve, which is observed in almost all disciplines. Some of these include psychology, business, economics, the sciences, nursing, and, of course, mathematics. Some instructors may use the normal distribution to help determine students’ grades. Most IQ scores are normally distributed. Often real-estate prices fit a normal distribution. The normal distribution is...
17.4K
01:19Normal Stress
1.5K
Normal stress is a type of stress that occurs when forces act perpendicular, or normal, to a material's cross-sectional area. This stress often arises in structures when subjected to axial loading, which is the application of force along the axis of an object. A practical example of this can be found in bridge truss members.
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...
1.5K
01:27C4 Pathway and CAM
49.4K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.4K
01:29Introduction to Normal Distributions
90
Standardized test scores often follow a symmetric distribution that can be modeled with the normal distribution, a fundamental concept in statistics. This distribution is particularly useful for interpreting test performance fairly across populations, as it provides a mathematical framework for understanding variability and central tendency in large datasets.From Histogram to Frequency DistributionRaw test data are often displayed using histograms, where the height of each bar represents the...
90
01:22Applications of Normal Distribution
9.5K
The normal distribution is a useful statistical tool. One of its practical applications is determining the door height after considering the normal distribution of heights of persons, such that many can pass through it easily without striking their heads. The normal distribution can also determine the probability of a person having a height less than a specific height.
The heights of 15 to 18-year-old males from Chile from 1984 to 1985 followed a normal distribution. The mean height is 172.36...
The heights of 15 to 18-year-old males from Chile from 1984 to 1985 followed a normal distribution. The mean height is 172.36...
9.5K
01:14Normal and Shear Force
3.4K
When a beam is subjected to different loads, such as weight, pressure, or other external forces, internal forces are generated within the beam. These forces can have a significant impact on the overall stability and strength of the structure. Engineers use various methods to analyze and determine the magnitude and direction of these internal forces. One common technique used to determine internal forces in beams is the method of sections. This method involves considering an imaginary point or...
3.4K