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Arterial stiffness association with chronic inflammatory disorders in the UK Biobank study

Alex Dregan1,2

  • 1School of Population Health Sciences, King's College London, London, UK.

Heart (British Cardiac Society)
|January 7, 2018
PubMed

Insights

Arterial stiffness is elevated in individuals with chronic inflammatory disorders. Increased inflammation biomarkers correlate with higher arterial stiffness, suggesting a link between inflammation and cardiovascular health.

Area of Science:

  • Cardiovascular Health
  • Inflammation Research
  • Biomarker Analysis

Background:

  • Arterial stiffness is a key indicator of cardiovascular risk.
  • Chronic inflammatory disorders are prevalent and associated with various health complications.
  • The relationship between arterial stiffness and inflammatory disorders requires further elucidation.

Purpose of the Study:

  • To test the hypothesis that arterial stiffness is elevated in individuals with inflammatory disorders compared to those without.
  • To investigate the association between specific inflammatory biomarkers and arterial stiffness.

Main Methods:

  • Utilized UK Biobank data from 171,125 adults aged 40-70, free of cardiovascular disease.
  • Assessed arterial stiffness using a non-invasive technique.
  • Analyzed chronic inflammatory disorders and inflammatory biomarkers (leukocytes, granulocytes) as exposures.

Main Results:

  • A 14% increase in mean arterial stiffness was observed in participants with chronic inflammatory disorders.
  • Arterial stiffness showed a positive trend with increasing tertiles of leukocytes and granulocytes.
  • Associations were noted with specific inflammatory conditions like psoriasis and rheumatoid arthritis.

Conclusions:

  • Arterial stiffness is significantly associated with multiple chronic inflammatory disorders.
  • Inflammatory biomarkers correlate with increased arterial stiffness, highlighting a potential pathway for cardiovascular risk.
  • Further research is warranted to explore arterial stiffness's predictive value for cardiovascular events in inflammatory conditions.
Abstract

Keywords:
aortic and arterial diseasecardiac imaging and diagnosticsepidemiologyinflammatory markerssystemic inflammatory diseases

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