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Circulating microparticles levels are increased in patients with diabetic kidney disease: A case-control research

Kathryna Fontana Rodrigues1, Nathalia Teixeira Pietrani1, Ana Paula Fernandes2

  • 1Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 7, 2018
PubMed
Abstract

Insights

Patients with type 2 diabetes and kidney disease show elevated levels of microparticles (MPs) linked to inflammation and cellular dysfunction. These findings highlight MPs as potential biomarkers for metabolic alterations in diabetic kidney disease.

Area of Science:

  • Endocrinology
  • Nephrology
  • Vascular Biology

Background:

  • Type 2 diabetes mellitus (T2DM) is characterized by chronic low-grade inflammation.
  • Microparticles (MPs) are cell-derived vesicles implicated in endothelial dysfunction in T2DM.
  • MPs exhibit pro-coagulant and pro-inflammatory properties relevant to T2DM pathophysiology.

Purpose of the Study:

  • To investigate the circulating microparticle (MP) profile in T2DM patients with diabetic kidney disease (DKD).
  • To correlate MP levels with clinical and laboratory parameters in DKD patients.

Main Methods:

  • Flow cytometry was used to quantify MPs derived from platelets (PMPs), leukocytes (LMPs), endothelial cells (EMPs), and tissue factor-expressing MPs (TFMPs).
  • Plasma samples from 39 DKD patients and 30 non-diabetic controls were analyzed.

Main Results:

  • DKD patients exhibited significantly higher levels of PMPs, LMPs, EMPs, and TFMPs compared to controls (p<0.0001).
  • Circulating MP levels in DKD were influenced by gender but not obesity or T2DM onset.
  • Fasting glucose and 25-hydroxyvitamin D levels correlated with MP levels in both groups.

Conclusions:

  • T2DM patients with DKD demonstrate increased levels of circulating MPs (PMPs, LMPs, EMPs, TFMPs).
  • Elevated MP levels in DKD are associated with specific metabolic alterations, suggesting their role in disease pathogenesis.
Keywords:
Diabetic kidney diseaseInflammationMicroparticlesObesityType 2 diabetes mellitusVitamin D

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