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Long noncoding RNAs: Undeciphered cellular codes encrypting keys of colorectal cancer pathogenesis
1The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
Cancer Letters
|January 7, 2018
Summary
Long noncoding RNAs (lncRNAs) are key players in colorectal cancer (CRC) development. This review highlights specific lncRNAs with potential as CRC biomarkers.
Area of Science:
- Molecular Biology
- Genomics
- Cancer Research
Background:
- Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, lacking protein-coding capacity.
- Advances in genetic and bioinformatic technologies have unveiled the significance of noncoding RNAs.
- lncRNAs play diverse cellular roles by interacting with DNA, proteins, and RNA.
Purpose of the Study:
- To review the functional roles of lncRNAs in various diseases, with a focus on cancer.
- To identify key long noncoding RNAs with high potential as colorectal cancer (CRC)-specific biomarkers.
Main Methods:
- Literature review of recent research on lncRNAs in CRC.
- Focus on identified and characterized lncRNAs in colorectal cancer.
- Analysis of lncRNA potential as biomarkers.
Main Results:
- lncRNAs have demonstrated functional roles in disease, including cancer.
- Colorectal cancer (CRC) research has significantly advanced the understanding of lncRNAs.
- Several notable lncRNAs have been identified and characterized in CRC.
Conclusions:
- lncRNAs are crucial in various biological processes and diseases.
- The study identifies specific lncRNAs as promising biomarkers for colorectal cancer.
- Further research into these lncRNAs could lead to improved CRC diagnostics.
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