Imaging Mycobacterial Trehalose Glycolipids
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Updated: Feb 16, 2026

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Mireille Kamariza1, Peyton Shieh1, Carolyn R Bertozzi2
1Stanford University, Stanford, CA, United States.
Abstract:
Cell surface trehalose mycolates are important modulators of mycobacterial pathogenesis and host immune response. We discuss the use of fluorescent and fluorogenic trehalose probes for the detection of the mycobacterial trehalose glycolipids. These probes enable real-time imaging of trehalose mycolate biosynthesis and mycomembrane dynamics in the laboratory as well as in clinical settings for the detection of mycobacteria in patient samples.
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