Related Experiment Video
Updated: Feb 16, 2026
Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
Published on: May 16, 2019
Effect of air bubbles localization and migration after embryo transfer on assisted reproductive technology outcome
Cem Fıçıcıoğlu1, Pınar Özcan2, Melis G Koçer1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Yeditepe University, İstanbul, Turkey.
Objective:
To evaluate the effect of embryo flash position and movement of the air bubbles at 1 and 60 minutes after ET on clinical pregnancy rates (PRs).
Design:
Prospective clinical trial.
Setting:
University fertility clinic.
Patient(S):
A total of 230 fresh ultrasound-guided ETs performed by a single physician (C.F.) at the IVF center of Yeditepe University Hospital between September 2016 and February 2017 were included.
Intervention(S):
Transabdominal ultrasonographic guidance at ET.
Main Outcome Measure(S):
Clinical PRs.
Result(S):
There was no significant difference in terms of clinical PRs between women with embryo flash located >15 mm and <15 mm from the fundus at 1 or 60 minutes (P=.6 and P=.7, respectively). The PRs in women with embryo flash located <15 mm and >15 mm from the fundus were 47% and 60%, respectively (P=.6). The clinical intrauterine PRs were 69.5%, 38.5%, and 19.1% in fundal, static, and cervical, respectively. The highest PR was in fundal when compared with others (P<.01). The clinical PR appears to be associated with the embryo flash movement/migration and the PR was dramatically reduced when the embryo migrated from its original position toward the cervix at 60 minutes.
Conclusion(S):
We concluded that clinical PR appears to be associated with the embryo flash movement/migration at 60 minutes after ET and embryo flash movement toward the fundus is associated with higher clinical PRs. Further well-designed randomized controlled trials are required to optimize ET technique in the future.
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