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Updated: Feb 16, 2026
08:39
Culture of Bladder Cancer Organoids as Precision Medicine Tools
Published on: December 28, 2021
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Concurrent chemoradiotherapy for bladder cancer: Practice patterns and outcomes in the general population
Ketan Ghate1, Kelly Brennan2, Safiya Karim3
1Department of Oncology, Queen's University, Kingston, Canada.
Summary
Chemoradiotherapy (CRT) significantly improves survival for muscle-invasive bladder cancer compared to radiation therapy (RT) alone. Increased CRT use in practice correlated with better survival outcomes for all patients receiving RT.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Oncology
Background:
- Clinical trials demonstrate chemoradiotherapy (CRT) superiority over radiation therapy (RT) alone for muscle-invasive bladder cancer.
- This study examines CRT uptake and comparative effectiveness in real-world clinical practice.
Purpose of the Study:
- To assess the adoption of CRT in routine practice for bladder cancer.
- To compare the effectiveness of CRT versus RT alone in terms of survival outcomes.
- To identify factors influencing CRT utilization.
Main Methods:
- Retrospective analysis of electronic treatment records linked to the Ontario Cancer Registry (1999-2013).
- Modified Poisson regression for CRT use factors; Cox models and propensity score analysis for survival (cancer-specific and overall).
Main Results:
- CRT use increased from 36% to 48% between 1999-2003 and 2009-2013.
- Younger age, lower comorbidity, and geographic region were associated with CRT use.
- CRT was linked to significantly improved cancer-specific survival (HR 0.70) and overall survival (HR 0.74) compared to RT alone.
Conclusions:
- Chemoradiotherapy is associated with superior survival outcomes compared to RT alone in muscle-invasive bladder cancer.
- Increased CRT uptake in the general population receiving RT correlated with improved survival.
- Significant geographic variations in CRT uptake were observed.
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