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The Frequency and Risk Factors for Ischemic Stroke in Myotonic Dystrophy Type 1 Patients

Kosuke Yoshida1, Yoko Aburakawa1, Yasuhiro Suzuki1

  • 1Department of Neurology, Asahikawa Medical Center, National Hospital Organization, Asahikawa, Hokkaido, Japan.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|January 8, 2018
PubMed

Insights

Ischemic stroke is linked to atrial fibrillation in myotonic dystrophy type 1 patients. High CHADS2 and CHA2DS2-VASc scores indicate increased risk, necessitating regular electrocardiograms for effective management.

Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Myotonic dystrophy type 1 (DM1) commonly presents with cardiac abnormalities, particularly conduction disorders.
  • Cerebral infarction in DM1 patients is understudied, prompting investigation into stroke frequency.

Purpose of the Study:

  • To determine the incidence of symptomatic and asymptomatic ischemic strokes in individuals with myotonic dystrophy type 1.
  • To evaluate the association between cardiac arrhythmias, stroke risk scores, and stroke occurrence in DM1 patients.

Main Methods:

  • Retrospective review of 108 diagnosed myotonic dystrophy type 1 patients.
  • Analysis of medical history, neuroimaging, electrocardiograms, and stroke risk scores (CHADS2, CHA2DS2-VASc).

Main Results:

  • Ischemic strokes were identified in 9 patients (6.9%), all with CHADS2 and CHA2DS2-VASc scores >2.
  • Atrial fibrillation was significantly more prevalent in patients with stroke (P < .001).
  • Significant differences in CHADS2 (P < .001) and CHA2DS2-VASc (P < .001) scores were observed between stroke and non-stroke groups.

Conclusions:

  • Ischemic stroke in myotonic dystrophy type 1 is associated with atrial fibrillation.
  • The CHADS2 score is a useful tool for managing stroke risk in DM1 patients.
  • Regular electrocardiogram monitoring is crucial for the clinical management of myotonic dystrophy type 1 patients.
Abstract

Keywords:
Myotonic dystrophy type 1atrial fibrillationatrial flutterischemic strokerisk factor

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