Related Experiment Video
Updated: Feb 16, 2026

A Rapid Method for Modeling a Variable Cycle Engine
Published on: August 13, 2019
Improving the success and impact of the metabolic engineering design, build, test, learn cycle by addressing proteins
1Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, United States; Interdepartmental Microbiology Graduate Program, Iowa State University, Ames, IA 50011, United States.
Abstract:
Rational, predictive metabolic engineering of organisms requires an ability to associate biological activity to the corresponding gene(s). Despite extensive advances in the 20 years since the Escherichia coli genome was published, there are still gaps in our knowledge of protein function. The substantial amount of data that has been published, such as: omics-level characterization in a myriad of conditions; genome-scale libraries; and evolution and genome sequencing, provide means of identifying and prioritizing proteins for characterization. This review describes the scale of this knowledge gap, demonstrates the benefit of addressing the knowledge gap, and demonstrates the availability of interesting candidates for characterization.
Related Concept Videos
Design Example: Sustainability in Concrete Building
There are multiple approaches to achieve sustainability in a commercial concrete building. For instance, construct a concrete parking area under the building, utilizing pervious concrete paver blocks in open areas to facilitate rainwater collection through an underground...
Ecological Succession
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
What is Metabolism?
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to...
Mechanical Protein Functions

