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Related Experiment Video

Updated: Feb 16, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

Published on: October 15, 2019

Imaging of a clickable anticancer iridium catalyst.

Xiuxiu Wang¹, Mingli Zhu¹, Fei Gao¹

¹State Key Laboratory of Coordination Chemistry, Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

Journal of Inorganic Biochemistry

|January 8, 2018

Summary

New iridium complexes show potent anticancer activity against ovarian cancer cells. These metallodrugs target mitochondria and can be tracked using bioorthogonal chemistry, aiding in understanding their mechanisms.

Keywords:

Anticancer CH activation Imaging Iridium Location

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Last Updated: Feb 16, 2026

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds

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Published on: October 15, 2019

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IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II

IridiumIII Luminescent Probe for Detection of the Malarial Protein Biomarker Histidine Rich Protein-II

Published on: July 7, 2015

Area of Science:

Medicinal Chemistry
Inorganic Chemistry
Cancer Biology

Background:

Iridium complexes are investigated for anticancer properties due to high cytotoxicity.
The antioxidant α-phenyl-N-tert-butylnitrone (PBN) can be modified to create novel metal-based drugs.

Purpose of the Study:

Synthesize and characterize new iridium complexes with potential anticancer activity.
Investigate the antiproliferation effects and cellular localization of these complexes.
Explore the use of bioorthogonal click chemistry for tracking metallodrugs in cancer cells.

Main Methods:

Synthesis and characterization of novel iridium complexes.
In vitro antiproliferation assays using human ovarian cancer A2780 cells.
Copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) for cellular imaging.
Fluorescent microscopy to determine cellular accumulation, particularly in mitochondria.

Main Results:

Complex 1-AMP demonstrated significant antiproliferation activity against A2780 cells.
Fluorescent imaging confirmed mitochondrial accumulation of complex 1-AMP via CuAAC.
SPAAC reactions in live cells validated mitochondrial targeting without copper catalyst cytotoxicity.

Conclusions:

Iridium complexes with nitrone ligands and azide groups show promise as anticancer agents.
The azide group facilitates tracking via bioorthogonal reactions, revealing mitochondrial localization.
These metallodrugs offer a valuable tool for studying anticancer mechanisms and drug delivery.