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Updated: Feb 16, 2026

Whole-Body Nanoparticle Aerosol Inhalation Exposures
Published on: May 7, 2013
A versatile generator of nanoparticle aerosols. A novel tool in environmental and occupational exposure assessment
Alberto Clemente1, M Pilar Lobera1, Francisco Balas1
1Instituto de Nanociencia de Aragón (INA), c/Mariano Esquillor s/n, 50018 Zaragoza, Spain; Networking Biomedical Research Centre of Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), c/Monforte de Lemos, 28040 Madrid, Spain.
Abstract:
The increasing presence of nanotechnology on the market entails a growing probability of finding ENMs in the environment. Nanoparticles aerosols are a yet unknown risk for human and environmental exposure that may normally occur at any point during the nanomaterial lifecycle. There is a research gap in standardized methods to assess the exposure to airborne nanoparticles in different environments. The controllable generation of nanoparticle aerosols has long been a challenging objective for researchers and industries dealing with airborne nanoparticles. In this work, a versatile system to generate nanoparticulate aerosols has been designed. The system allows the production of both i) instantaneous nanoparticle clouds and ii) continuous nanoparticle streams with quasi-stable values of particle concentration and size distribution. This novel device uses a compressed-air pressure pulse to disperse the target material into either the testing environment (instantaneous cloud formation) or a secondary chamber, from which a continuous aerosol stream can be drawn, with a tunable nanoparticle concentration. The system is robust, highly versatile and easy to operate, enabling reproducible generation of aerosols from a variety of sources. The system has been verified with four dry nanomaterials: TiO2, ZnO, CuO and CNT bundles.
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