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Iron overload impact on P-ATPases.

Leilismara Sousa1, Marco Tulio C Pessoa1, Tamara G F Costa1

  • 1Laboratório de Bioquímica Celular, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João del Rei, Av Sebastião Gonçalves Coelho, 400, Divinópolis, MG, 35501-296, Brazil.

Annals of Hematology
|January 8, 2018
PubMed
Summary

Iron overload impacts vital P-ATPases, affecting cellular ion transport and homeostasis. While activating Fe2+-ATPase, it inhibits Ca2+-ATPase and variably affects Na+,K+-ATPase across tissues.

Keywords:
Ca2+-ATPaseFe2+-ATPaseIron overloadNa+,K+-ATPaseOxidative stressP-type ATPase

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Iron is essential for life but toxic in excess, stimulating lipid peroxidation.
  • P-ATPases, including Na+,K+-ATPase, Ca2+-ATPase, and Fe2+-ATPase, are crucial for cellular functions.
  • Iron's impact on these ATPases is complex and tissue-dependent.

Purpose of the Study:

  • To investigate the effects of iron overload on key P-ATPases.
  • To elucidate the mechanisms by which iron influences ATPase activity and cellular homeostasis.
  • To highlight the tissue-specific responses to iron overload.

Main Methods:

  • Review of existing literature on iron metabolism and ATPase function.
  • Analysis of experimental data on iron's interaction with Na+,K+-ATPase, Ca2+-ATPase, and Fe2+-ATPase.
  • Discussion of the physiological consequences of altered ATPase activity.

Main Results:

  • Iron overload activates Fe2+-ATPase, reducing intracellular iron.
  • Iron overload inhibits Ca2+-ATPase, disrupting calcium gradients and potentially causing enzyme damage.
  • Iron overload inactivates Na+,K+-ATPase in renal, brain, and heart cells but stimulates it in erythrocytes.

Conclusions:

  • Iron overload significantly modulates P-ATPase activity, impacting ion transport and cellular homeostasis.
  • Tissue-specific effects of iron on Na+,K+-ATPase highlight the complexity of iron toxicity.
  • Understanding these interactions is crucial for addressing iron-related pathologies.