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Targeting the stroma in pancreatic cancer

Daniel H Ahn1, Ramesh K Ramanathan2

  • 1Department of Hematology/Medical Oncology, Mayo Clinic Cancer Center, Phoenix, AZ, USA.

Chinese Clinical Oncology
|January 9, 2018
PubMed

Keywords:
Microenvironmentimmunotherapypancreatic cancerstromatargeted therapies

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The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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