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Related Concept Videos

Mutations01:39

Mutations

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Overview
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Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
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Reproductive Cloning01:27

Reproductive Cloning

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Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
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Viral Mutations00:36

Viral Mutations

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Asexual Reproduction02:38

Asexual Reproduction

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Asexual reproduction allows plants to reproduce without growing flowers, attracting pollinators, or dispersing seeds. Offspring are genetically identical to the parent and produced without the fusion of male and female gametes.
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Overview of the Reproductive System01:31

Overview of the Reproductive System

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The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
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Ultrasonography in Experimental Reproductive Investigations on Rats
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BRCA mutations and reproduction.

Hagit Daum1, Tamar Peretz2, Neri Laufer3

  • 1Department of Genetic and Metabolic Diseases, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Fertility and Sterility
|January 9, 2018
PubMed
Summary
This summary is machine-generated.

BRCA1 and BRCA2 gene mutations increase cancer risk. This review examines the limited research on fertility in BRCA carriers, highlighting a gap in understanding this crucial aspect for affected individuals.

Keywords:
BRCApreimplantation genetic diagnosis (PGD)premature ovarian insufficiency

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Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
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Area of Science:

  • Genetics and Oncology
  • Reproductive Health

Background:

  • Deleterious mutations in BRCA1 or BRCA2 genes are established risk factors for breast and ovarian cancers.
  • Extensive research exists on BRCAness pathophysiology, surveillance, and prophylaxis.
  • The impact of these mutations on fertility remains under-investigated.

Purpose of the Study:

  • To conduct a comprehensive literature review on the fertility of individuals carrying BRCA1 or BRCA2 mutations.

Main Methods:

  • Systematic review of existing scientific literature.
  • Analysis of studies investigating reproductive outcomes in BRCA mutation carriers.

Main Results:

  • Limited data available on BRCA carrier fertility.
  • Potential implications for family planning and reproductive choices.

Conclusions:

  • There is a significant need for further research into the fertility of BRCA mutation carriers.
  • Understanding fertility impacts is crucial for comprehensive genetic counseling and patient care.