Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

2.9K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.9K
Microorganisms in Agriculture and Food industry01:27

Microorganisms in Agriculture and Food industry

1.6K
Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
1.6K
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

272
A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of...
272
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.2K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peanut Component-Specific IgE and IgG4 Are Modulated by Sublingual Immunotherapy and Are Associated With Remission in 1-4-Year-Old Children.

Allergy·2025
Same author

Baseline basophil activation and early suppression is associated with clinical outcome after peanut sublingual immunotherapy.

The Journal of allergy and clinical immunology·2025
Same author

Efficacy and safety of epicutaneous immunotherapy in children with peanut allergy with atopic comorbidities.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2025
Same author

To Eat or Not to Eat - Oral Immunotherapy for High-Threshold Peanut Allergy.

NEJM evidence·2025
Same author

Efficacy and Safety of Epicutaneous Immunotherapy in Peanut-Allergic Toddlers: Open-Label Extension to EPITOPE.

The journal of allergy and clinical immunology. In practice·2025
Same author

Epicutaneous immunotherapy for the treatment of peanut allergy.

Allergy·2024

Related Experiment Video

Updated: Feb 16, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

26.6K

Treatment for food allergy.

A Wesley Burks1, Hugh A Sampson2, Marshall Plaut3

  • 1Department of Pediatrics, University of North Carolina, Chapel Hill, NC.

The Journal of Allergy and Clinical Immunology
|January 9, 2018
PubMed
Summary

Food allergy immunotherapy research explores various delivery methods like oral, sublingual, and epicutaneous routes. While oral immunotherapy shows efficacy, other methods offer better safety and tolerability for patients.

Keywords:
Food allergyepicutaneous immunotherapyfood immunotherapyoral immunotherapysublingual immunotherapy

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.6K
A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.1K

Related Experiment Videos

Last Updated: Feb 16, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

26.6K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.6K
A Treatment Package without Escape Extinction to Address Food Selectivity
04:23

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

12.1K

Area of Science:

  • Immunology
  • Allergy and Immunology
  • Public Health

Background:

  • IgE-mediated food allergy affects millions globally, posing a significant public health challenge.
  • Current management relies on strict dietary avoidance, with no approved therapeutic treatments available.
  • Research is actively investigating various food immunotherapy approaches to address this unmet need.

Purpose of the Study:

  • To review and compare different routes of food immunotherapy for treating IgE-mediated food allergies.
  • To evaluate the efficacy, safety, and tolerability profiles of oral, sublingual, and epicutaneous immunotherapy.
  • To explore emerging strategies and next-generation treatments in food allergy immunotherapy.

Main Methods:

  • Review of existing research on oral immunotherapy (OIT), sublingual immunotherapy (SLIT), and epicutaneous immunotherapy (EPIT).
  • Analysis of studies investigating adjuvants and anti-IgE therapies to enhance immunotherapy outcomes.
  • Examination of early-phase studies and animal models for novel immunotherapy concepts.

Main Results:

  • Oral immunotherapy demonstrates high efficacy in increasing the amount of tolerated food protein.
  • Sublingual and epicutaneous immunotherapy offer improved safety and tolerability compared to OIT.
  • EPIT provides the best safety and tolerability profile, though with potentially less protection.

Conclusions:

  • Food immunotherapy, particularly OIT, SLIT, and EPIT, represents a promising therapeutic avenue for food allergies.
  • Balancing efficacy with safety and tolerability is crucial in selecting the optimal immunotherapy approach.
  • Ongoing research into novel strategies and next-generation treatments holds potential for advancing food allergy management.