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New lignans attenuating cognitive deterioration of Aβ transgenic flies discovered in Acorus tatarinowii
Wei-Yang Zhang1, Xiao-Lin Feng2, Dan Lu2
1State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, PR China.
Abstract:
Five new lignan racemates, (±)-tatarinoid D-H (1-5), and three known analogues (6-8) were isolated from the rhizomes of Acorus tatarinowii. Their structures were established by 1D, 2D-NMR, HR-MS, IR and optical spectral data. Among them, 1 and 6-8 can alleviate the cognitive deterioration of Aβ transgenic flies.
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