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Related Experiment Videos

Reward processing dysfunction in ventral striatum and orbitofrontal cortex in Parkinson's disease.

Stéfan du Plessis1, Meija Bossert2, Matthijs Vink3

  • 1Department of Psychiatry, Stellenbosch University, South Africa.

Parkinsonism & Related Disorders
|January 9, 2018
PubMed
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Parkinson's disease impairs reward processing in the brain, affecting both anticipation and outcome. These abnormalities in the fronto-striatal reward system are specific to Parkinson's disease and not caused by aging.

Area of Science:

  • Neuroscience
  • Neurology
  • Dopamine Neurotransmission

Background:

  • Parkinson's disease (PD) prevalence increases with global longevity.
  • Aging and PD both affect dopamine neurotransmission.
  • Investigating the impact on the fronto-striatal reward system is crucial.

Purpose of the Study:

  • To investigate the effects of Parkinson's disease on the orbitofrontal and ventral striatal reward system.
  • Focus on patients with moderate to severe clinical symptoms.

Main Methods:

  • Utilized a monetary incentive delay (MID) task.
  • Compared 17 Parkinson's disease patients to two age-stratified control groups.
  • MID task activates ventral striatum (reward anticipation) and orbitofrontal cortex (reward outcome).
Keywords:
Orbitofrontal cortexParkinson's diseaseReward processingVentral striatum

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Main Results:

  • Parkinson's disease patients showed abnormal activity in the ventral striatum during reward anticipation.
  • Abnormal activity was also observed in the orbitofrontal cortex during reward outcome processing.
  • No significant effects of aging were detected on these reward processes.

Conclusions:

  • Parkinson's disease causes abnormalities in both reward anticipation and outcome processing.
  • Orbitofrontal cortex dysfunction in PD may be specific, as it's less affected by normal aging.
  • Findings highlight the impact of PD on the fronto-striatal reward system.