Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

588
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
588
Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

12.3K
The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
12.3K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

4.2K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.2K
Microbial Morphologies01:29

Microbial Morphologies

4.2K
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
4.2K
Microbial Fermentation01:23

Microbial Fermentation

1.6K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.6K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

4.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut Microbiota Shapes the Effects of Saturated and Polyunsaturated Fatty Acids on Skin and Hair Follicle Homeostasis.

The Journal of investigative dermatology·2026
Same author

The Gut Microbiome in Surgical Oncology: Mechanisms, Perioperative Outcomes, and Therapeutic Opportunities.

The British journal of surgery·2026
Same author

The expanding role of the microbiome in GLP-1 pharmacology.

Cell host & microbe·2026
Same author

Gut microbe-derived <i>N</i>-acyl serinol lipids shape host postprandial metabolic homeostasis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen.

Cell reports·2026
Same author

Gut Microbe-Derived Trimethylamine Shapes Circadian Rhythms Through the Host Receptor TAAR5.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Feb 16, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K

Microbial modulation of cardiovascular disease.

J Mark Brown1, Stanley L Hazen1

  • 1Department of Cellular and Molecular Medicine, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, NC-10, Cleveland, Ohio 44195, USA.

Nature Reviews. Microbiology
|January 9, 2018
PubMed
Summary

Diet impacts cardiovascular disease (CVD) risk through gut microbes. Targeting host-microorganism interactions shows promise for preventing and treating CVD by modulating microbial metabolism and metabolites.

More Related Videos

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.7K
Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases
10:53

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases

Published on: June 16, 2022

9.9K

Related Experiment Videos

Last Updated: Feb 16, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.3K
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.7K
Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases
10:53

Dissection Techniques and Histological Sampling of the Heart in Large Animal Models for Cardiovascular Diseases

Published on: June 16, 2022

9.9K

Area of Science:

  • Microbiology
  • Cardiovascular Science
  • Metabolism

Background:

  • Diet is a known factor in cardiovascular disease (CVD) pathogenesis.
  • Recent research highlights the complex interplay between nutrient intake, gut microbiota, and host responses in modifying CVD risk.

Purpose of the Study:

  • To review current knowledge on gut microbial mechanisms driving CVD.
  • To emphasize therapeutic interventions targeting host-microorganism interactions.
  • To highlight the need for causal links between microbial pathways and CVD.

Main Methods:

  • Review of existing literature on gut microbiota and CVD.
  • Analysis of microbial metabolites (e.g., trimethylamine-N-oxide, short-chain fatty acids, bile acids) and their role in CVD.
  • Examination of host pattern recognition receptors sensing microbial-associated molecular patterns.

Main Results:

  • Gut microbiota significantly influences CVD pathogenesis through microbial metabolites and molecular patterns.
  • Host pattern recognition receptors interact with microbial components, potentially driving CVD.
  • Microbial metabolites like trimethylamine-N-oxide, SCFAs, and secondary bile acids are key players.

Conclusions:

  • Targeting host-microorganism interactions presents a promising strategy for CVD prevention and treatment.
  • Further research is needed to establish definitive causal links between specific microbial pathways and CVD pathogenesis.