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Published on: September 6, 2024
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Tropical Fevers in Indian Intensive Care Units: A Prospective Multicenter Study
Sunit Singhi1, Narendra Rungta2, Karthi Nallasamy3
1Professor Emeritus Pediatrics, PGIMER, Chandigarh, Haryana, India.
Summary
Tropical fevers like dengue and scrub typhus are common in Indian ICUs, causing organ failure. Early diagnosis and treatment are crucial for better outcomes in critically ill patients.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Public Health
Background:
- Tropical fevers often present with undifferentiated symptoms and organ failures.
- A nationwide study was conducted to understand tropical fevers in Indian Intensive Care Units (ICUs).
Purpose of the Study:
- To identify the prevalence, clinical profile, resource utilization, and outcomes of tropical fevers in Indian ICUs.
- To inform diagnostic and therapeutic strategies for tropical fevers.
Main Methods:
- A multicenter prospective observational study involving 34 ICUs across India.
- Enrolled critically ill adults and children with nonlocalizing fever and signs of organ dysfunction.
Main Results:
- Dengue, scrub typhus, encephalitis, and malaria were the most common etiologies.
- High rates of mechanical ventilation, vasoactive therapy, and renal replacement therapy were observed.
- Mortality was 18.4%, with higher rates in patients with undiagnosed etiology.
Conclusions:
- Dengue, scrub typhus, encephalitis, and malaria are leading causes of tropical fevers in Indian ICUs.
- A syndromic approach, point-of-care tests, and empiric antimicrobial therapy are recommended.
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