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Cationic disulfide-functionalized worm gels.

L P D Ratcliffe1, K J Bentley1, R Wehr1

  • 1Dainton Building , Department of Chemistry , University of Sheffield , Brook Hill , Sheffield , South Yorkshire S3 7HF , UK . Email: l.p.ratcliffe@gmail.com ;

Polymer Chemistry
|January 9, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed cationic disulfide-functionalized worm gels using polymerization-induced self-assembly (PISA). This novel method creates advanced hydrogels with potential mucoadhesive properties for various applications.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Polymerization-induced self-assembly (PISA) enables rational synthesis of diblock copolymer worms.
  • Traditional methods for worm gel synthesis are often complex and require dilute solutions.

Purpose of the Study:

  • To explore a new synthetic route for aqueous dispersions of cationic disulfide-functionalized worm gels.
  • To utilize PISA for creating functionalized block copolymer worms.

Main Methods:

  • Synthesis of poly[(glycerol monomethacrylate-stat-glycidyl methacrylate)]-block-poly(2-hydroxypropyl methacrylate) (P(GMA-stat-GlyMA)-PHPMA) block copolymer worms via RAFT aqueous dispersion polymerization.
  • Reaction of cystamine with epoxy groups to introduce disulfide and cationic functionalities.
  • Characterization using GPC, NMR, TEM, DLS, electrophoresis, and rheology.

Main Results:

  • Successfully synthesized cationic disulfide-functionalized worm gels via PISA.
  • Demonstrated control over cross-linking density by varying the cystamine/epoxy ratio, yielding either chemically cross-linked or physically cross-linked worm gels.
  • Characterized the worm gels, confirming their structure and properties.

Conclusions:

  • A novel PISA-based method for synthesizing cationic disulfide-functionalized worm gels has been established.
  • The synthesized hydrogels possess tunable properties and may exhibit enhanced mucoadhesive characteristics.
  • These findings open avenues for developing advanced functional hydrogels for biomedical applications.